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April 1970

Epinephrine Effects on Corneal Cells in Tissue Culture

Author Affiliations

New York
From the Eye Bank for Sight Restoration, Inc., and the Glaucoma Service, Manhattan Eye, Ear, and Throat Hospital, New York. Dr. Krejci was a visiting research fellow from Prague. His present address is Prague 3-Zizkov, Jeseniova 186, Czechoslovakia.

Arch Ophthalmol. 1970;83(4):451-454. doi:10.1001/archopht.1970.00990030451012

Rabbit, dog, and human corneal epithelium was studied in tissue culture for the effect of epinephrine at 0.001% concentration. Degenerative changes in the epithelial cells appeared within 24 to 48 hours. Loosened cells and increased optical density of cell nuclei were followed by increased granularity and vacuolation. Melanin or melanin-like material was deposited after 216 to 240 hours, and there was formation of giant vacuoles. The pigment was not only extracellular but present in the cytoplasm and nuclei.

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