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April 1970

Vitreous Hemorrhage: An Experimental Study: III. Experimental Degeneration of the Rabbit Retina Induced by Hemoglobin Injection Into the Vitreous

Arch Ophthalmol. 1970;83(4):470-474. doi:10.1001/archopht.1970.00990030470016

Early degeneration of the rabbit retina after hemoglobin injection into the vitreous was studied by light and electron microscopy. Structural changes including a pyknotic change in rod nuclei and early rod degeneration were apparent three days after injection. Electron-dense bodies began to appear within the degenerating pigment epithelium cells on the seventh day. These bodies may be degenerating products of outer rod segments.

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