[Skip to Content]
[Skip to Content Landing]
June 1970

Collagenolytic Activity in the Cornea of the Metamorphosing Tadpole

Author Affiliations

From the Department of Cornea Research, Retina Foundation, Boston.

Arch Ophthalmol. 1970;83(6):760-764. doi:10.1001/archopht.1970.00990030760016

Collagenase was demonstrated in the epithelium in eight of ten corneal explants of thyroxineinduced metamorphosing tadpoles. There was no detection of collagenase in explants of "resting" control tadpoles, or in explants denuded of their epithelium in the metamorphosing series. The implications of such an enzyme in the morphological changes occurring in the cornea which accompany metamorphosis are discussed.