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July 1970

Guanethidine Ophthalmic Solution 5%: Use in the Treatment of Endocrine Exophthalmos

Author Affiliations

Walnut Creek, Calif
From the Department of Ophthalmology, Permanente Medical Group, Kaiser Foundation Hospital, Walnut Creek, Calif.

Arch Ophthalmol. 1970;84(1):21-24. doi:10.1001/archopht.1970.00990040023006

The effectiveness of guanethidine ophthalmic solution 5% as treatment for endocrine exophthalmos was tested in seven patients in a 14-day double-blind study. The drug produced statistically significant ptosis in three of the seven patients and decreased intraocular pressure in four. Five percent guanethidine solution appears to be a useful agent in the treatment of this difficult ophthalmic disease.

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