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August 1970

Granular Dystrophy of the Cornea: Characteristic Electron Microscopic Lesion

Author Affiliations

New York
From the Cornea Service and Cornea Research Laboratory, Department of Ophthalmology, New York Hospital-Cornell Medical Center, New York.

Arch Ophthalmol. 1970;84(2):179-192. doi:10.1001/archopht.1970.00990040181011

THERE have been four formal reports on the ultrastructure of granular dystrophy (Groenouw's type 1).1-4

Sornson (1965)1 studied the stromal cells of granular dystrophy. He described an increase in activity of these cells as evidenced by an increase in the endoplasmic reticulum. Other cells were noted to have vacuoles of varying sizes, and finally there was obvious cell degeneration. These changes are presently recognized as nonspecific since they are found in many conditions, ie, trauma, wound healing, dystrophies, and inflammation.

In 1965, McTigue2 described a single electron micrograph of a cornea with granular dystrophy that showed a single electron dense stromal mass. Teng (1967)3 reported changes similar to Sornson's in the stromal cells. He also demonstrated accumulations of fine filaments approximately 50 Angstroms long in the stroma.

In the Japanese literature Matsuo et al (1967)4 and Kuwabara et al (1967)5 did not observe filaments