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August 1970

Experimental Amblyopia in Monkeys: I. Behavioral Studies of Stimulus Deprivation Amblyopia

Author Affiliations

From the Wilmer Institute of Ophthalmology, the Johns Hopkins University School of Medicine and Hospital (Drs. von Noorden and Dowling) and the Department of International Health, the Johns Hopkins School of Hygiene (Dr. Ferguson), Baltimore.

Arch Ophthalmol. 1970;84(2):206-214. doi:10.1001/archopht.1970.00990040208014

Rhesus monkeys were visually deprived unilaterally by surgical closure of the eyelids at different ages after birth. The animals were subsequently conditioned to respond to Landolt rings in different positions to determine visual acuity. After acuity thresholds were established for the nondeprived eye, it was surgically closed; the deprived eye was opened, and the acuity of the deprived eye was measured. The results reveal that severe visual impairment without recovery was caused by lid closure during the first four weeks of life. If lid closure was performed at three months or afterwards, the deprived eye showed rapid functional recovery when the lids were reopened. The electroretinograms in two monkeys with stimulus deprivation amblyopia were normal.

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