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September 1970

Angiopathy of Retinal Vessels in Diabetic Mice

Author Affiliations

From the Wills Eye Hospital and Research Institute, Philadelphia.

Arch Ophthalmol. 1970;84(3):316-320. doi:10.1001/archopht.1970.00990040318011

An inbred line of Japanese mice established in 1957 and named the "KK Strain" has been studied for many attributes of its congenital diabetes. This study documents the occurrence of angiopathy in the retinal vessels and contrasts these findings to a similar sized and aged control group of nondiabetic Swiss Webster mice. Studies were made on flat retinal preparations following intracardiac injection of 4% silver nitrate and 3% thiodiglycol in water. Vascular constrictions, dilations, microaneurysms, mural thickening, and proliferation of connective tissue were shown in increasing incidents in the KK mice as they became older.

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