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September 1970

II. The Pathogenesis of Recurrent Immunologic (Auer) Uveitis

Author Affiliations

San Francisco
From the Department of Pathology and Laboratory of Ocular Inflammatory Disease, Department of Ophthalmology, University of California School of Medicine, San Francisco.

Arch Ophthalmol. 1970;84(3):331-341. doi:10.1001/archopht.1970.00990040333013

These experiments clearly demonstrate the causal role of circulating antigen-antibody complexes in recurrent immunologic (Auer) uveitis and allow a precise definition of the pathogenesis of this experimental model and its extrapolation to attempt to explain the development of recurrent uveitis in man. Severe primary inflammation of the uveal tract, regardless of etiology, causes a persistent increase in uveal vascular permeability. This in turn results in the selective deposition of circulating antigen-antibody complexes in the uveal tract when conditions are favorable to the formation of immune complexes in the circulation. The presence of complexes in the uveal tissues attracts numerous polymorphonuclear leukocytes to the site resulting in the development of an acute, recurrent uveitis which is usually self-limited but which may persist or repeatedly recur, with eventual severe chronic sequelae and blindness.

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