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September 1970

Toxicity of the Cyanoacrylates

Author Affiliations

San Francisco
From the Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California, Medical Center, San Francisco.

Arch Ophthalmol. 1970;84(3):342-349. doi:10.1001/archopht.1970.00990040344014

Evaluation of toxicity in the cyanoacrylate adhesives and their homologs was undertaken in conventional and germ free guinea pigs. Adhesive was applied to the denuded cornea centrally and peripherally and injected intrastromally; all experimental models demonstrated in vivo toxicity. Intrastromal injection and surface application to the central cornea produced the severe inflammatory response in both species.