Asymmetrical cupping of the optic disc was found in 5.6% of normal individuals, in 30% of a group with ocular hypertension without field defect, and in 36% of those with established chronic open-angle glaucoma and field loss. Disc asymmetry was also instrumental in leading to the diagnosis of subacute angle-closure glaucoma and of chronic vascular insufficiency of the optic nerve. The search for disc asymmetry is an essential part of glaucoma screening.
Fishman RS. Optic Disc Asymmetry: A Sign of Ocular Hypertension. Arch Ophthalmol. 1970;84(5):590–594. doi:10.1001/archopht.1970.00990040592006
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