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November 1970

Oxygen Poisoning of the Eyes: Comparison in Cyanotic and Acyanotic Dogs

Author Affiliations

From the departments of ophthalmology, pathology, surgical pathology (Dr. Yanoff), pediatrics (Dr. Miller), and surgery (Dr. Waldhausen), Hospital and Medical School of the University of Pennsylvania, and Division of Cardiology (Dr. Miller), Children's Hospital of Philadelphia, Philadelphia. Dr. Miller is now with the Department of Pediatrics, University of Texas (Southwestern) Medical School, Dallas. Dr. Waldhausen is now with the Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pa.

Arch Ophthalmol. 1970;84(5):627-629. doi:10.1001/archopht.1970.00990040629014

Fourteen eyes from acyanotic dogs exposed to 1 atmosphere of 100% oxygen for 48 to 50 hours developed both uveal and retinal detachments. The primary alteration seemed to be leakage of fluid from the choroidal vasculature probably due to a toxic effect of the increased arterial oxygen tensions (Po2) on the endothelial cells of the choriocapillaris. The retinal detachment appeared to be secondary to leakage of fluid from the choroid into the subretinal space. None of the 14 eyes from the cyanotic dogs showed any pathologic alterations. The oxygen administration in the cyanotic dogs did not cause any significant increase in the Po2.