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November 1970

The Pathogenesis of Suture Toxicity

Author Affiliations

San Francisco
From the Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California, Medical Center, San Francisco.

Arch Ophthalmol. 1970;84(5):641-644. doi:10.1001/archopht.1970.00990040643017

The ability of both silk and nylon suture to activate the acute inflammatory pathways was evaluated by comparative γ-globulin binding of the two sutures. Quantitative binding was determined by the amount of radioisotopically labeled IgG was bound by segments of silk and nylon suture; qualitative binding was evaluated by absorption of fluorescein-labeled human γ-globulin and complement. These studies indicated that silk suture has a marked propensity over nylon to bind γ-globulin and that silk suture bound considerably more protein than nylon suture.