[Skip to Navigation]
December 1970

Suture Toxicity in the Germfree Guinea Pig

Author Affiliations

Bethesda, Md
From the Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, and the Eye Research Laboratories, Department of Ophthalmology and the Clinical Laboratories, University of California School of Medicine, San Francisco General Hospital (Drs. McMaster, Aronson, and Moore), San Francisco.

Arch Ophthalmol. 1970;84(6):776-782. doi:10.1001/archopht.1970.00990040778017

Some 10-0 monofilament nylon (Ethilon) (22.1μ diameter), 9-0 and 8-0 silk, and 7-0 collagen sutures were tied to the corneas of germfree guinea pigs to determine the effects of suture toxicity in a controlled environment. Of the sutures tested, 10-0 nylon demonstrated the mildest reaction and 8-0 silk the most severe inflammatory reaction.

Add or change institution