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January 1971

Corticosteroid Therapy in Metastatic Endophthalmitis

Author Affiliations

San Francisco
From the Ocular Inflammatory Disease Service and Department of Ophthalmology, San Francisco General Hospital, University of California School of Medicine, San Francisco. Dr. Sussman is now with the Department of Pediatrics, St. Christopher's Hospital for Children, Philadelphia.

Arch Ophthalmol. 1971;85(1):61-70. doi:10.1001/archopht.1971.00990050063009

This study presents nine cases of confirmed metastatic endophthalmitis. Seven patients underwent immunologic evaluation. All patients were treated with locally and systemically administered antibiotics; six patients received local corticosteroid in addition to the antibiotic. Four patients died during hospitalization. Of the seven eyes (five patients) treated with combined corticosteroid therapy, all showed improvement, two attained a visual acuity of >20/200, and four achieved a visual acuity of >20/40. Immunologic evaluation revealed some abnormality in all seven patients tested. This finding is discussed as it affects the relationship of host response and infectious agent to the disease process.

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