The comparative effects of isosorbide and glycerin on lowering of intraocular tension (IOT) were studied in 54 patients. With isosorbide, a greater fall occurred in 31 patients; while with glycerin, a greater fall occurred in 23. Besides lowering IOT, isosorbide produced significantly fewer side reactions than glycerin.
Mehra KS, Singh R, Char JN, Rajyashree K. Lowering of Intraocular Tension: Effects of Isosorbide and Glycerin. Arch Ophthalmol. 1971;85(2):167–168. doi:10.1001/archopht.1971.00990050169009
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