Interocular protein transfer was demonstrated after intravitreal injection of isotopically labeled bovine serum albumin into one eye of rabbits. The transfer of the trace molecule occurs by a nonhematogenous pathway. These experiments indicate that cerebrospinal fluid route and/or the ipsilateral optic nerve-chiasm-contralateral optic nerve are probably not the pathway mediating nonhematogenous interocular protein transfer.
Hasty ND, Higginbotham RW, Andrews JS, Elliott JH. Nonhematogenous Interocular Protein Transfer: I. Validity and Possible Routes. Arch Ophthalmol. 1971;85(3):309–314. doi:10.1001/archopht.1971.00990050311014
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