A patient treated for an inflamed pinguecula with 1% medrysone (HMS) developed a typical delayed hypersensitivity reaction. This was established as a reaction to the medrysone rather than to any of the substances in the vehicle.
Smolin G. Medrysone Hypersensitivity: Report of a Case. Arch Ophthalmol. 1971;85(4):478–479. doi:10.1001/archopht.1971.00990050480015
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