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May 1971

Ocular Localization of Sodium Fluorescein: Effects of Administration in Rabbit and Monkey

Author Affiliations

From the Department of Ophthalmology, University of Pennsylvania Medical School, Philadelphia. Dr. Grayson is on leave of absence as Senior Registrar in Ophthalmology, Welsh National School of Medicine, Cardiff, Wales.

Arch Ophthalmol. 1971;85(5):600-609. doi:10.1001/archopht.1971.00990050602014

The localization of intravenously administered fluorescein was studied in rabbit and monkey by fluorescence microscopy of freeze-dried eyes. The blood vessels, large and small, of retina and optic nerve are impermeable to fluorescein. Although fluorescein diffuses rapidly throughout the choroid, none passes the pigment epithelium to enter the retina. In contrast, at the posterior scleral foramen some fluorescein enters the optic disc by diffusion from neighboring tissues.