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June 1971

Retinitis Pigmentosa and Lymphocytic Leukemia

Arch Ophthalmol. 1971;85(6):699-702. doi:10.1001/archopht.1971.00990050701009

THE OCULAR manifestations of retinitis pigmentosa and lymphocytic leukemia are each well documented in the ophthalmic literature.1-6 Recently, a patient with the unique combination of both disorders was hospitalized at the National Institutes of Health (NIH). It is the purpose of this report to document this unusual combination of unrelated conditions.

Report of a Case  The patient (NIH 08-13-37), a white 53-year-old woman, was referred to the Solid Tumor Service, National Cancer Institute, in April 1969, with a four-month history of asymptomatic cervical lymph node enlargement. A node biopsy done elsewhere showed replacement of the tissue with abnormal small lymphocytes consistent with the diagnosis of well-differentiated lymphocytic lymphoma.This patient observed difficulty with night vision at age 20 years. The diagnosis of retinitis pigmentosa was first made at age 27 years. From age 20 years, the patient noticed deterioration in her ability to adapt in darkness and a constriction

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