Studies were conducted to evaluate the strength and durability of isobutyl 2-cyanoacrylate bonds in vivo. The shear strength of silicone-sclera and silicone-silicone adhesive joints was tested in rabbit eyes during a one- and three-month period, respectively. Also, 63 sutureless scleral buckling operations were performed on rabbit eyes. At various intervals over 12 months, the eyes were enucleated for gross and histologic examination. Silicone-silicone adhesive joints remained strong in vivo, but silicone-sclera bonds weakened after several months. Because of the dangers of migration and extrusion of implanted materials, a completely sutureless technique for routine retinal detachment surgery is not recommended at this time. However, technical advances may make sutureless retinal surgery practical in the future.
Calabria GA, Pruett RC, Refojo MF. Further Experience With Sutureless Scleral Buckling Materials: II. Cyanoacrylate Tissue Adhesive. Arch Ophthalmol. 1971;86(1):82–87. doi:10.1001/archopht.1971.01000010084016
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