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September 1971

Collagenase Activity of Intact Corneal Epithelium in Peripheral Alkali Burns

Author Affiliations

From the Department of Cornea Research, Retina Foundation, and the Howe Laboratory, Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1971;86(3):308-313. doi:10.1001/archopht.1971.01000010310014

Collagenase was produced from intact epithelium of nonulcerated rabbit corneas beginning 9 to 15 hours after an alkali burn of the perilimbal sclera. At the same time, glycogen loss from these cells generally paralleled the degree of aqueous glucose depression. Aqueous humor from alkali burned eyes failed to have either facilitative or inhibitory effects on collagenase production in vitro. Persistently low aqueous pH starting 20 minutes after peripheral alkali burning is attributed to increased aqueous lactate.

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