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November 1971

Passive Transfer of Experimental Allergic Uveitis

Author Affiliations

San Francisco; Bethesda, Md
From the Eye Research Laboratories, Department of Ophthalmology, San Francisco General Hospital, University of California School of Medicine. San Francisco (Dr. Aronson), and the Laboratory of Microbial Immunity, National Institute of Allergic and Infectious Diseases, Bethesda, Md (Dr. McMaster).

Arch Ophthalmol. 1971;86(5):557-563. doi:10.1001/archopht.1971.01000010559013

Experimental allergic uveitis was produced normal strain XIII guinea pigs by passive transfer of cells from strain XIII animals with chronic uveitis. Donor cells were transferred by either intravenous (IV) or intraperitoneal (IP) injection to 16 normals; seven developed clinical signs of uveitis, four within 48 hours of IV injection and three within four days of IP injection. Clinically, the inflammation was characterized by limbal hyperemia, injection of iris vasculature, anterior chamber cells and flare, and small foci of fibrin adjacent to the pupillary margin. The histologic reaction in the initial stage was predominated by polymorphonuclear leukocytes; in the later lymphoidal stage, the small or large lymphocyte predominated.