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November 1971

Steroid Inhibition of Leukocyte Defense System in Mycoplasmal Uveitis

Author Affiliations

From the Howe Laboratory of Ophthalmology, Harvard Medical School, and the Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1971;86(5):575-582. doi:10.1001/archopht.1971.01000010577017

Inoculation of the microorganism Mycoplasma pulmonis into the anterior chamber of the rabbit eye elicits a marked plasma cell-lymphocytic inflammatory response in the uveal tract. Because of the known inhibitory effect of corticosteroid drugs on the white blood cell immune response, the effect of exogenous local steroid on known Mycoplasma uveitis was evaluated. This model demonstrates the exquisite and adverse sensitivity of lymphocyte to steroids, the relative intensity of the antibody-producing plasma cells, and the inhibition of normal macrophage digestive function probably through steroid stabilization of the lysosomal membranes.