This report describes a reversible, systemic disturbance that included bilateral internal opththalmoplegia, methacholine chloride (Mecholyl) hypersensitivity, and areflexia. Although some aspects of the syndrome have been observed previously (classic Adie's syndrome), the systemic disturbances and reversibility have not been reported previously. The etiology remains obscure.
Weintraub MI, Ribner JA, Gallagher BB. Transient Internal OphthalmoplegiaAreflexia and Methacholine Hypersensitivity With Unidentified Systemic Disease. Arch Ophthalmol. 1971;86(5):595–598. doi:10.1001/archopht.1971.01000010597019
* * SCHEDULED MAINTENANCE * *
The JAMA Network Sites will be conducting routine maintenance from 10/20/2017 through 10/21/2017. During this window access to content and authentication may be intermittently available. The JAMA Store will be completely unavailable during the maintenance window.