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December 1971

Corneal Glucose Flux: II. Its Response to Anterior Chamber Blockade and Endothelial Damage

Arch Ophthalmol. 1971;86(6):685-691. doi:10.1001/archopht.1971.01000010687013

The flux of glucose at the anterior stromal surface of the cornea is 575 nanomol/sq cm/hr in anesthetized rabbits. Blockade of the endothelial surface with air and silicone oil reduces the glucose flux to less than 20% of normal, reflecting the small amount of glucose which is available to the epithelium from the limbus. Blood in the anterior chamber reduces the flux to about 50% of normal. Interference with normal endothelial function by mechanical or thermal damage increases the movement of glucose across the cornea, which may indicate that the endothelium ordinarily acts as a relative permeability barrier to glucose penetration from the aqueous humor into the corneal stroma.