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January 1972


Arch Ophthalmol. 1972;87(1):111. doi:10.1001/archopht.1972.01000020113021

To the Editor.  —Although not recognized as such, the case reported as "Ocular Cystine Deposits in an Adult" (Arch Ophthal85:690-694, 1971) may well represent a different eye disorder with a specific metabolic defect. However, the studies are incomplete and thus deprive those interested in biochemical anomalies of the eye of an answer.Whether the case reported represents one of adult cystinosis is in question. All but one of the reported cases with adult cystinosis had in addition to corneal cystine deposits, similar cystine accumulations in the bone marrow.1,2 It is not stated in the paper whether or not conjunctival cystine (by paper chromatography) was found in excessive amounts, whether control samples had been tested for cystine, and whether cholesterol or other lipids or amino acids were tested for in the biopsy material.It is disturbing that in attempting to link their findings to cystinosis the authors