Heterogeneous in vitro degradation of poly (β 14C-isobutyl 2-cyanoacrylate) suggest that isobutyl cyanoacrylate surgical adhesive will gradually be absorbed when used in vivo. Experiments of tissue penetration by the adhesive were carried out in vitro in calf eyes and in vivo in rabbit eyes. Radioactive monomer was applied respectively to the surface of the cornea denuded of epithelium, and the polymerized adhesive was implanted intracorneally. The adhesive cannot penetrate the cornea, and in the time intervals of the experiments (up to nine weeks in vivo) no radioactive degradation products of the adhesive were found in the inner eye tissues by radioactive counts of the humors and inner tissues of the eyes.
Sani BP, Refojo MF. β14C-Isobutyl 2-Cyanoacrylate Adhesive: Determination of Absorption in the Cornea. Arch Ophthalmol. 1972;87(2):216–221. doi:10.1001/archopht.1972.01000020218020
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