A nontoxic, nonirritating fluorescent stain, bis-(N, N-bis-(carboxymethyl)-aminoethyl)-fluorescein tetrasodium salt (Fluorexon) (BCA), has been evaluated. Because it does not readily stain hydrophilic, soft contact lenses, it can be used to assess the tear exchange around a soft contact lens while on the eye of a patient.
Refojo MF, Miller D, Fiore AS. A New Fluorescent Stain for Soft Hydrophilic Lens Fitting. Arch Ophthalmol. 1972;87(3):275–277. doi:10.1001/archopht.1972.01000020277007
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