Corneal stroma previously damaged by herpes simplex virus (HSV) did not yield virus or cause seroconversion when transplanted into normal rabbit eyes. After penetrating keratoplasty, the recipient rabbits were observed for up to 15 months for evidence of keratitis, virus shedding, or seroconversion. Although five episodes of corneal ulceration occurred, two of them in contralateral ungrafted eyes, HSV was not recovered on culture, and seroconversion did not occur, even following challenge with corticosteroids and ultraviolet irradiation.
Darrell RW. Penetrating Grafts Using Herpes Convalescent Cornea. Arch Ophthalmol. 1972;87(4):411–416. doi:10.1001/archopht.1972.01000020413010
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