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May 1972


Arch Ophthalmol. 1972;87(5):595. doi:10.1001/archopht.1972.01000020597022

To the Editor.  —I should like to point out an inaccuracy in the final section of the article "Hypoglycemia and Infantile Cataract" in the November 1971 issue of the Archives (86:495-498) by Merin and Crawford.The authors state that the "infantile cataract associated with galactosemia is assumed to be caused by inhibition of glucose-6-phosphate dehydrogenase." This is based on a series of papers by Lerman1 in which evidence is presented purporting to show an inhibitory effect of galactose-1-phosphate on glucose-6-phosphate dehydrogenase. This sugar phosphate is known to accumulate in the tissues of galactosemic patients. However, Korc2 has shown that incubation of normal lens homogenates with galactose-1-phosphate does not affect the activity of glucose-6-phosphate dehydrogenase. Kinoshita3 has also been unable to confirm Lerman's observations. Weinberg and Segal,4 studying galactosemic leukocytes, have shown that abnormally high amounts of galactose-1-phosphate do not inhibit glucose metabolism via the hexosemonophosphate

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