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July 1972

Saccadic Eye Movements in Myasthenia Gravis

Author Affiliations

San Francisco
From the Smith-Kettlewell Institute of Visual Sciences, San Francisco.

Arch Ophthalmol. 1972;88(1):9-11. doi:10.1001/archopht.1972.01000030011003

The velocity of saccadic eye movements was recorded by electrooculography in myasthenic and control subjects before and after edrophonium chloride (Tensilon) administration. Increased saccadic velocity and an increase in frequency and amplitude of the optokinetic nystagmus followed edrophonium administration in the myasthenic subjects. No changes occurred in the control subjects. Saccadic velocity testing in myasthenia gravis can be performed simply and rapidly. The eye movement study must be made in the direction of the apparent ocular motor weakness. The test is free of discomfort and provides a sensitive, objective response. It is indicated when ocular motor function improvement is judged equivocal by the subject or by the examiner grossly observing eye movements.

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