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August 1972

Fusarium solani Keratitis Treated With Natamycin (Pimaricin): Eighteen Consecutive Cases

Author Affiliations

Miami, Fla
From the Department of Ophthalmology, Bascom Palmer Eye Institute, and the Department of Dermatology, University of Miami School of Medicine, Miami, Fla.

Arch Ophthalmol. 1972;88(2):147-154. doi:10.1001/archopht.1972.01000030149004

Natamycin (pimaricin) as a 5% suspension, was used sucessfully in 16 of 18 consecutive Fusarium solani corneal ulcers between February 1969 and January 1971. Thirteen of these patients obtained a visual result of 20/40 or better. These results compare favorably with a series of 20 Fusarium ulcers treated with amphotericin B prior to February 1969. Amphotericin B was effective in eliminating the fungus in only seven patients, five of whom retained a visual acuity of 20/40 or better. These results suggest that a 5% suspension of natamycin should be the initial therapy in F solani keratitis.

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