Natamycin (pimaricin) as a 5% suspension, was used sucessfully in 16 of 18 consecutive Fusarium solani corneal ulcers between February 1969 and January 1971. Thirteen of these patients obtained a visual result of 20/40 or better. These results compare favorably with a series of 20 Fusarium ulcers treated with amphotericin B prior to February 1969. Amphotericin B was effective in eliminating the fungus in only seven patients, five of whom retained a visual acuity of 20/40 or better. These results suggest that a 5% suspension of natamycin should be the initial therapy in F solani keratitis.