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August 1972

Studies in Uveal Physiology: III. Anterior Chamber Clearance, Uveoretinal Distribution, and Respiratory Response Associated With Zinc 69m

Author Affiliations

Hartford, Conn
From the Department of Surgery, University of Connecticut Health Center (Drs. O'Rourke, Durrani, and Mr. Benson), and the departments of bio-engineering (Dr. Bronzino) and physics (Dr. Miller), Trinity College, Hartford, Conn.

Arch Ophthalmol. 1972;88(2):185-192. doi:10.1001/archopht.1972.01000030187010

Reports of concentrations of zinc in uveal and retinal tissues prompted this study of anterior chamber clearance, tissue distribution, and influence on oxygen consumption associated with zinc chloride 69m. Clearance of 69mZn as zinc chloride occurred at 0.72% per minute. Distribution to uveal and retinal tissues was most specific and highest following intracameral microinjection of the tracer. Another divalent ion, phosphorus 32, was studied: it cleared from the anterior chamber at 0.99% per minute but showed no preferential uveal or retinal distribution. Consumption of oxygen in vitro by uveal and retinal tissues was trebled following addition of trace amounts of 69mZn to the bathing media. These findings suggest that zinc ion may be an important trace element in uveal and retinal metabolism; its turnover by these tissues might be studied in appropriately designed clinical experiments.