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August 1972

Ocular Absorption of Indomethacin by the Rabbit

Author Affiliations

Little Rock, Ark
From the departments of ophthalmology and pharmacology, University of Arkansas Medical Center, Little Rock, Ark.

Arch Ophthalmol. 1972;88(2):196-198. doi:10.1001/archopht.1972.01000030198012

Water suspension and oil solution of 1% indomethacin-2-14C was administered to the rabbit eye. Following topical administration to the cornea, the drug was soon detected in the aqueous fluid, iris, and cornea of the eye, with the persistence of the drug being noted up to six hours. The intraocular penetration of indomethacin was enhanced by inflammation. Subconjunctival administration of the drug resulted in poor penetration of the compound into the intraocular tissues or fluids in both inflamed and normal eyes.