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In January 1969, an ad hoc seminar and workshop on Spiral Organisms in Body Fluids was held at the Venereal Disease Research Laboratories in Atlanta. The committee was made up of many of the recognized experts in the field: James N. Miller, Virginia H. Falcone, Bruce Golden, Charles W. Israel, U.S.G. Kuhn III, and Robert M. Smibert. Within two years this committee, under the leadership of Dr. Miller, has produced an excellent manual of investigative methods in spirochetal disease. The text is well organized and indexed, written in concise outline form, and covers the pathogenesis and clinical manifestations of experimentally induced treponemal disease in rabbits and primates as well as detailed descriptions of laboratory techniques of obtaining, handling, and evaluating body tissues and fluids. Forty-two pertinent references are given as well as the names and locations of commercial companies where reagents and sera may be obtained and reference laboratories where