Forty-one patients with Wagner's vitreoretinal degeneration were studied. The polymorphous ocular signs of this disease included vitreous changes, myopia, cataract, retinal pigmentation, retinal breaks, patchy areas of thinned pigment epithelium or of chorioretinal atrophy, narrowing or sheathing of the retinal vessels, extensive white with pressure, lattice degeneration, marked meridional folds, optic atrophy and subnormal or normal electroretinograms. The main cause of blindness was retinal detachment of relatively poor surgical prognosis due to a variety of causes. Various types of retinal breaks were found in close association with vitreous and retinal disease. Early diagnosis of this disease is important. Members of the patient's family should be checked for retinal breaks. Prophylactic treatment for retinal detachment should be considered before cataract develops.
Hirose T, Lee KY, Schepens CL. Wagner's Hereditary Vitreoretinal Degeneration and Retinal Detachment. Arch Ophthalmol. 1973;89(3):176–185. doi:10.1001/archopht.1973.01000040178003
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