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April 1973

Pupillary Autonomic Functions in Heterochromia Iridis

Author Affiliations

Waverley, Mass
From the Walter E. Fernald State School, Waverley, Mass.

Arch Ophthalmol. 1973;89(4):291-292. doi:10.1001/archopht.1973.01000040293006

Drug-induced changes in pupillary size were recorded photographically in eight subjects with heterochromia iridis (HI) and in eight controls.

The patients with HI showed excessive mydriasis with 1% epinephrine, absent response to 4% cocaine, normal mydriasis with 1% atropine and miosis with 2.5% methacholine.

Both pupils responded in a similar fashion, suggesting a bilateral defect of sympathetic innervation of the iris.

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