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June 1973

Fibroblastic Ingrowth Following Cataract Extraction

Author Affiliations

Portland, Ore.
From the John E. Weeks Institute of Ophthalmology, University of Oregon Medical School. Portland, Ore.

Arch Ophthalmol. 1973;89(6):445-449. doi:10.1001/archopht.1973.01000040447001

Limbal wounds heal by ingrowth of subepithelial connective tissue. This tissue, rather than stromal overgrowth, is the primary source of the fibroblasts which sometimes invade the anterior chamber after cataract extraction. In normal healing, bridging of the inner wound by endothelium seems to confine fibroplasia to the stromal defect, even when there is gaping of the inner edges. Factors inciting fibroblastic ingrowth include recurrent hemorrhage, uveitis, tissue incarcerations, and reaction to bulky, poorly placed, and tightly tied sutures. Endothelial damage predisposes to a fibroblastic retrocorneal membrane which may be difficult to differentiate from epithelial downgrowth. The course is variable and treatment ineffective but avoidance of scleral incisions and factors which incite fibroplasia provides a basis for preventing fibroblastic ingrowth.

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