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June 1973

Blood-borne Candida Endophthalmitis: A Clinical and Pathologic Study of 21 Cases

Author Affiliations

Los Angeles
From the departments of ophthalmology (Drs. Griffin and Pettit) and pathology (Dr. Foos), Jules Stein Eye Institute, and the Department of Medicine, Division of Infectious Diseases (Dr. Fishman), UCLA School of Medicine, Los Angeles.

Arch Ophthalmol. 1973;89(6):450-456. doi:10.1001/archopht.1973.01000040452002

Candidemia may be followed by hematogenous Candida endophthalmitis. Six clinical cases and 15 postmortem cases in which focal retinal or chorioretinal lesions developed following candidemia are presented. Common clinical features include a history of gastrointestinal or biliary tract disease, recent surgery, prolonged use of intravenous catheters, recent bacterial sepsis, and intensive treatment with systemically administered antibiotics. Early treatment with antifungal drugs appears efficacious. It is proposed that a search for intraocular lesions be performed in every patient with candidemia and that discovery of such a lesion be a strong indication for treatment with amphotericin B.

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