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August 1973

Argon Laser Photocoagulation of Choroidal Malignant Melanoma: Tissue Effects After a Single Treatment

Author Affiliations

Suzanne Levi, Chicago
From the departments of ophthalmology and pathology, University of Illinois Eye and Ear Infirmary, Chicago.

Arch Ophthalmol. 1973;90(2):97-101. doi:10.1001/archopht.1973.01000050099004

Argon laser photocoagulation of choroidal malignant melanomas from a 54-year-old man and a 46-year-old woman was carried out. The globes were enucleated 24 hours postcoagulation and studied histopathologically. Because the tumors studied were flat, heavily vascularized, and (in one of the cases) pigmented, they would theoretically appear to be candidates for destruction by argon therapy. Tumor cell necrosis was seen only in the superficial aspect of the masses after a single treatment, however, and extensive fragmentation and breakdown of tumor vessels with associated hemorrhage occurred. Such vessel damage is dangerous because an increased potential for vascular invasion (with subsequent tumor seeding or metastasis) is created.

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