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September 1973

Afferent Arc of the Corneal Immunologic Reaction: II. Local and Systemic Response to Bovine γ-Globulin

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology (Dr. Smolin) and the Department of Ophthalmology (Dr. Hall), University of California, San Francisco.

Arch Ophthalmol. 1973;90(3):231-234. doi:10.1001/archopht.1973.01000050233010

After the unilateral intracorneal injection of rabbit eyes with bovine γ-globulin, many antibody-producing cells were found in the homolateral lymph nodes, cornea, and uveal tract. The greatest number of plaqueforming cells per million cells was found in the uveal tract between 12 and 15 days postinjection. No appreciable numbers of such cells were present in the contralateral lymph nodes or in the spleen. These studies indicate that the immunologic response to the intracorneal injection of foreign protein is confined essentially to the local lymph nodes and to antibody-producing tissues of the eye.