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October 1973

Ocular Response to Corticotropin in Myasthenia Gravis

Author Affiliations

From the Department of Neurology, University of Tennessee College of Medicine, Memphis.

Arch Ophthalmol. 1973;90(4):292-293. doi:10.1001/archopht.1973.01000050294008

Twenty-two patients who had myasthenia gravis with ptosis, ophthalmoparesis, or both, were treated with massive doses of corticotropin (adrenocorticotrophic hormone). The ocular symptoms in eight of the patients improved significantly. Subsequently, four patients who failed to improve with corticotropin therapy had thymectomies, followed by corticotropin or prednisone treatment. Three of these patients had significant improvement of their ocular symptoms. Combining the different modes of therapy, a total of 50% of the patients had enough improvement of their ocular symptoms to be classified as functionally normal.