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December 1973

Comparison of Types 1 and 2 Herpesvirus hominis Infection of Rabbit Eyes: I. Clinical Manifestations

Arch Ophthalmol. 1973;90(6):473-476. doi:10.1001/archopht.1973.01000050473015

The clinical manifestations of infection of rabbit eyes with type 2 Herpesvirus hominis (HVH) were compared with the manifestations of a comparable type 1 HVH infection. The principal ocular changes that followed dropping virus of both types onto intact corneas were conjunctivitis, corneal ulceration, pannus, and iritis. Regardless of passage history, all eight strains of type 1 HVH caused superficial keratitis of early onset that healed rapidly without corneal scarring, and the conjunctivitis and iritis were mild or only moderately severe and of short duration. In contrast, all but one of the seven strains of type 2 HVH were much slower to produce lesions, but the lesions were much more severe and of longer duration; an extensive, deep stromal keratitis was regularly produced and eventuated in corneal opacification, total pannus, and scarring.