Brown-black pigmentation of hydrophilic lenses worn by three patients occurred within two months after concurrent epinephrine compound therapy was begun. In one case, dense pigmentation occurred in less than two weeks. Although no ocular damage resulted, considerable emotional trauma was experienced by one patient and his family prior to diagnosis of his apparently "black eye." In all cases the lenses were discarded.
Sugar J. Adrenochrome Pigmentation of Hydrophilic Lenses. Arch Ophthalmol. 1974;91(1):11–12. doi:10.1001/archopht.1974.03900060015004
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