Proctase-treated collagen gels were injected into the vitreous cavity in 16 patients with retinal detachments that were considered inoperable by current scleral buckling techniques. Opacification of the gels and a transient inflammatory response were observed, but the vitreous cavity cleared within two weeks in 11 of the 16 eyes (69%). Anatomic reattachment was obtained in three patients (19%), and useful vision was recovered by two patients (13%). Further investigation is necessary before collagen gel can be recommended as an adjunct to retinal detachment surgery.
Pruett RC, Schepens CL, Freeman HM. Collagen Vitreous Substitute: II. Preliminary Clinical Trials. Arch Ophthalmol. 1974;91(1):29–32. doi:10.1001/archopht.1974.03900060033008
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