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January 1974

Collagenase Inhibitors in Pseudomonas Keratitis: Adjuncts to Antibiotic Therapy in Rabbits

Author Affiliations

San Francisco; Camp Lejeune, NC
From the Naval Hospital and Naval Medical Field Research Laboratory, Camp Lejeune, NC (Drs. Bohigian, Valenton, and Caraway), and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco (Mr. Okumoto). Dr. Bohigian is now at Washington University School of Medicine, St. Louis; Dr. Valenton, at the Philippine Eye Research Institute, Manila, Philippines; and Dr. Caraway, US Air Force Base, Torrejón de Ardoz, Spain.

Arch Ophthalmol. 1974;91(1):52-56. doi:10.1001/archopht.1974.03900060056014

Collagenase inhibitors as adjuncts to antibiotic therapy were evaluated in experimentally induced Pseudomonas keratitis in rabbits. Neither the combination of 1% edetic acid (EDTA) and 0.25% polymyxin B sulfate nor that of 1.2% cysteine and 0.25% polymyxin B sulfate was more effective than the polymyxin B sulfate alone. There was a small statistical difference in favor of a combination of edetic acid-cysteine-polymyxin B sulfate when it was compared with an edetic acid-polymyxin B sulfate combination. This difference, although statistically significant, did not appear to be clinically important in the treatment of our experimental model.