[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
April 1974

Experimental Immunogenic Orbital Inflammation

Author Affiliations

San Francisco
From the Department of Ophthalmology and the Eye Research Laboratories, San Francisco General Hospital, University of California School of Medicine, and the Eyetis Foundation, San Francisco.

Arch Ophthalmol. 1974;91(4):303-307. doi:10.1001/archopht.1974.03900060313014

Acute orbital inflammation has been induced by injecting bovine serum albumin into the retrobulbar space of rabbits that have been systemically immunized to the same antigen. The principal clinical signs of proptosis, conjunctival chemosis, and lid swelling appear within three hours after injection and are most severe after 24 hours. Signs of anterior chamber reaction, cells and flare, appear as early as two hours after injection.

Histologic changes consist of a polymorphonuclear (PMN) cell infiltration throughout the orbit including muscle, optic nerve sheaths, perivascular and subconjunctival spaces. The optic nerve itself is spared. The choroid and the outer layer of the retina show changes as early as six hours after injection. Maximum reaction of massive PMN cell infiltration occurs by 24 hours after injection.

It is proposed that the widespread inflammation is due to direct diffusion of antigen throughout the orbit and along the vessels into the choroid.