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June 1974

Acute Optic Neuropathy: Treatment With Diphenylhydantoin

Author Affiliations

St. Louis
From the Department of Ophthalmology, Washington University School of Medicine, St. Louis. Dr. Ellenberger is a Fellow in Neuro-ophthalmology.

Arch Ophthalmol. 1974;91(6):435-438. doi:10.1001/archopht.1974.03900060449003

Previous reports have suggested that diphenylhydantoin may improve visual field loss resulting from ischemic disease of the optic nerves. Therefore, 15 patients with residual visual impairment after acute, presumably ischemic, optic neuropathy were treated alternately with diphenylhydantoin sodium and placebo in a double-blind study. Neither visual acuity nor visual fields improved during treatment. The importance of careful quantitative perimetry with preliminary repetitive testing until results are reproducible is stressed.