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September 1974

Corneal Absorption of Fluorometholone in Rabbits: A Comparative Evaluation of Corneal Drug Transport Characteristics in Anesthetized and Unanesthetized Rabbits

Author Affiliations

From the School of Pharmacy, University of Wisconsin, Madison.

Arch Ophthalmol. 1974;92(3):240-243. doi:10.1001/archopht.1974.01010010248016

A single drop of tritium-labeled 0.1% fluorometholone suspension was administered topically to intact eyes of anesthetized and unanesthetized rabbits. Aqueous humor levels of steroid were monitored as a function of time. The aqueous humor drug concentration-time profile for anesthetized rabbits is considerably different from that for unanesthetized animals. Anesthetized animals show a shift in the time to achieve a maximum aqueous humor steroid concentration, which is ascribed to a change in rate-limiting step from corneal absorption control to dissolution control. In addition, aqueous humor drug levels in the anesthetized rabbits were dependent on position of the animals and level of anesthesia.