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September 1974

Experimental Corneal Wound Strength: Effect of Topically Applied Corticosteroids

Author Affiliations

From the Department of Ophthalmology, College of Medicine, University of Florida, Gainesville. Dr. Sugar is now with the Department of Ophthalmology, Washington University School of Medicine, St. Louis. Dr. Chandler is now with the Department of Ophthalmology, University of Washington, Seattle.

Arch Ophthalmol. 1974;92(3):248-249. doi:10.1001/archopht.1974.01010010256018

Dexamethasone, 0.1%, was administered topically to rabbits three times daily at various intervals after they sustained central corneal wounds. The eyes treated during the first postoperative week demonstrated significantly diminished wound tensile strength compared to either the contralateral eyes or untreated controls. Eyes treated during the third postoperative week had no reduction in corneal wound tensile strength.